Thimet Oligopeptidase (THOP1) Mouse Monoclonal Antibody [Clone ID: 4D6]

Specifications

Product Data
Clone Name	4D6
Applications	ICC/IF, IHC, WB
Recommend Dilution	Immunohistochemistry: 1:400, Immunocytochemistry/ Immunofluorescence: 1:10-1:500, Western Blot: 1:750-1:3000, Immunohistochemistry-Paraffin: 1:400
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	A synthetic peptide corresponding to residues 56-72 of human thimet oligopeptidase.
Formulation	Tris-glycine and 150mM NaCl and 0.05% sodium azide
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	thimet oligopeptidase 1
Database Link	NP_003240 Entrez Gene 7064 Human UniProt ID P52888
Background	A steady-state level of amyloid beta-peptide (Abeta) represents a balance between its biosynthesis from the amyloid precursor protein (APP) through the action of the beta and gamma-secretases and its catabolism by a variety of proteolytic enxymes. Thimet Oligopeptidase (THOP1) has been shown to promote A-beta degradation. It has also been shown to play a role in antigen presentation, metabolism of neuropeptides under 20 amino acids, and cytoplasmic peptide degradation.
Synonyms	EP24.15; MEPD_HUMAN; MP78; TOP
Reference Data
Protein Families	Druggable Genome, Protease
Protein Pathways	Renin-angiotensin system

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