PI 3 Kinase Class 3 (PIK3C3) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ICC/IF, Simple Western, WB
Recommend Dilution	Immunocytochemistry/ Immunofluorescence: 1:100, Western Blot: 1:1000, Simple Western: 1:20, Knockdown Validated
Reactivity	Human, Rat, Mouse, Porcine
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide made to an internal portion of the human protein (within residues 700-850). [Swiss-Prot# Q8NEB9]
Formulation	PBS, 0.1% BSA, 50% glycerol and 0.05% Sodium Azide
Purification	peptide affinity purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	phosphatidylinositol 3-kinase catalytic subunit type 3
Database Link	NP_002638 Entrez Gene 65052 RatEntrez Gene 225326 MouseEntrez Gene 5289 Human UniProt ID Q8NEB9
Background	VPS34, also known as phosphoinositide-3-kinase p100 subunit or PIK3C3 (phosphoinositide-3-kinase, class III), is a member of the PI3/PI4-kinase family. It is ubiquitously expressed with predominant expression in skeletal muscle and is believed to participate in endosome to lysosome transport, multivesicular body formation, autophagy and retrograde endosome to Golgi transport. VPS34 is the catalytic subunit of class III PI3Ks and forms a heterodimer with p150, a regulatory subunit of class 3 PI3Ks. It exclusively phosphorylates phosphatidylinositol to produce PtdIns3P. The activity of VPS34 is enhanced by manganese and can be regulated by nutrients, suggesting an important role of VPS34 in the regulation of mTOR protein synthesis. VPS34 also forms a complex with Beclin1 that promotes autophagy and tumor supression.
Synonyms	hVps34; VPS34; Vps34
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Inositol phosphate metabolism, Metabolic pathways, Phosphatidylinositol signaling system, Regulation of autophagy

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