BIRC5 Mouse Monoclonal Antibody [Clone ID: 32.1]

CAT#: TA301427

Mouse Monoclonal Antibody against Survivin (32.1)



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CNY 5,381.00


货期*
5周

规格
    • 100 ul

Cited in 2 publications.

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经常一起买 (4)
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Specifications

Product Data
Clone Name 32.1
Applications ELISA, FC, ICC/IF, IHC, IP, WB
Recommend Dilution ELISA, Immunoprecipitation, Immunohistochemistry: 20 ug/ml, Immunocytochemistry/ Immunofluorescence: 1:10-1:500, Western Blot: 1:1000, Flow Cytometry, Immunohistochemistry-Paraffin: 20 ug/ml
Reactivity Human
Host Mouse
Clonality Monoclonal
Immunogen Recombinant human survivin, full-length
Formulation PBS with 0.02% Sodium Azide
Concentration lot specific
Purification Protein G purified
Conjugation Unconjugated
Storage Condition Store at -20°C as received.
Gene Name baculoviral IAP repeat containing 5
Background Regulated inhibition of programmed cell death (apoptosis) preserves normal homeostasis and tissue and organ morphogenesis. Aberrations in this process contribute to human diseases and cancer by abnormally prolonging cell viability. Recently, several apoptosis inhibitors related to the baculovirus iap gene have been found in various species, including human. IAP proteins contain one/three Cys/His baculovirus IAP repeats plus a c-terminus RING finger and are thought to block an evolutionary conserved step in apoptosis. Survivin encodes a structurally unique inhibitor of apoptosis (IAP). Survivin expression is turned off during fetal development and is not found in non-neoplastic adult human tissues. Survivin becomes abundantly re-expressed in transformed cells and in all of the most common cancers of lung, colon, pancreas, breast and prostate in vivo. Survivin appears to be situated at the crossroads of cell death and cell division, governing a checkpoint involved in cytokinesis while also suppressing apoptosis. Survivin is also abundantly expressed in brain tissues (astrocytes and some neurons) of adult rats following traumatic brain injury. Survivin has been found co-expressed with NeuN (mature neuronal marker) and PCNA (a cell cycle protein). Survivin might affect regulation of neural cell proliferative responses after brain injury.
Synonyms API4; EPR-1
Reference Data
Protein Families Druggable Genome, Stem cell - Pluripotency
Protein Pathways Colorectal cancer, Pathways in cancer
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

Citations (2)

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