Prostaglandin D Synthase (PTGDS) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	Western Blot: 2 ug/ml
Reactivity	Human, Feline, Bovine, Rabbit, Dog, Rat, Mouse, Primate
Host	Rabbit
Clonality	Polyclonal
Immunogen	The epitope recognized by this antibody maps to region within residue 120-190 of human PTGDS. [Swiss-Prot# P41222]
Formulation	PBS + 30% glycerol and 0.1% sodium azide
Concentration	lot specific
Purification	Immunogen affinity purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	prostaglandin D2 synthase
Database Link	NP_000945 Entrez Gene 19215 MouseEntrez Gene 25526 RatEntrez Gene 403740 DogEntrez Gene 5730 Human UniProt ID P41222
Background	The protein encoded by this gene is a glutathione-independent prostaglandin D synthase that catalyzes the conversion of prostaglandin H2 (PGH2) to postaglandin D2 (PGD2). PGD2 functions as a neuromodulator as well as a trophic factor in the central nervous system. PGD2 is also involved in smooth muscle contraction/relaxation and is a potent inhibitor of platelet aggregation. PTGDS has also been implicated in the development and maintenance of the blood-brain, blood-retina, blood-aqueous humor and blood-testis barrier. Studies with transgenic mice overexpressing this gene suggest that this gene may be also involved in the regulation of non-rapid eye movement (NREM) sleep. It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system. PTGDS is the most abundant protein in the cerebral spinal fluid and recent evidence suggests that PTGDS acts as a Beta-Amyloid chaperone and may have a role in the deposition of Ab plaques in Alzheimer? disease.
Synonyms	L-PGDS; LPGDS; PDS; PGD2; PGDS; PGDS2
Reference Data
Protein Pathways	Arachidonic acid metabolism, Metabolic pathways

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