pagA Rabbit Polyclonal Antibody

CAT#: TA160055

Rabbit Polyclonal Anti-Anthrax Protective Antigen Antibody



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CNY 5,808.00


货期*
4周

规格
    • 100 ug

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Specifications

Product Data
Recommend Dilution ELISA: 1 ug/mL
Reactivity Bacteria
Host Rabbit
Clonality Polyclonal
Immunogen Anthrax protective antigen antibody was raised against a synthetic peptide corresponding to 14 amino acids at the carboxy terminus of the Anthrax protective antigen protein.
Formulation PBS containing 0.02% sodium azide.
Concentration 1 mg/ml
Purification Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation Unconjugated
Storage Condition Store at -20°C as received.
Background Anthrax Protective Antigen Antibody: Anthrax infection is initiated by the inhalation, ingestion, or cutaneous contact with Bacillus anthracis endospores. B. anthracis produces three polypeptides that comprise the anthrax toxin: protective antigen (PA), lethal factor (LF), and edema factor (EF). PA binds to two related proteins on the cell surface; these are termed tumor epithelial marker 8 (TEM8)/anthrax toxin receptor (ATR) and capillary morphogenesis protein 2 (CMG2), although it is still unclear which is physiologically relevant. Following PA binding to its receptor, PA is cleaved into two fragments by a furin-like protease. The bound fragment binds both LF and EF; the resulting complex is then endocytosed which allows the translocation of LF and EF into the cytoplasm. These toxins are usually sufficient to cause rapid cell death, and often the death of the organism.
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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