TLR7 (451-500) Mouse Monoclonal Antibody [Clone ID: 4F4]

Specifications

Product Data
Clone Name	4F4
Applications	ELISA, FC, IF, WB
Recommend Dilution	ELISA. Immunocytochemistry / Immunofluorescence. Flow cytometry.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant human TLR7 (451-500 aa) purified from E. coli
Specificity	The antibody recognizes TLR7 at aa 451-500.
Formulation	PBS, pH 7.4 containing 0.02% Sodium Azide and 10% Glycerol State: Purified State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Protein-G affinity chromatography
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for up to two weeks or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	toll like receptor 7
Database Link	Entrez Gene 51284 Human UniProt ID Q9NYK1
Background	TLR7 is one of toll-like receptors which are type I transmembrane proteins involved in innate immunity by recognizing microbial conserved structures. These proteins are characterized by multiple copies of leucine rich repeats in the extracellular domain and IL-1 receptor motif in the cytoplasmic domain, and act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors. Human TLR7(hTLR7) is predominantly expressed in lung, placenta and spleen and hTLR7,8 genes are located on the sex chromosome X. hTLR7 may play an important role in detecting and combating viral infections.
Synonyms	Toll-like receptor 7
Reference Data

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