Alpha B Crystallin (CRYAB) Mouse Monoclonal Antibody [Clone ID: 2E8]

Specifications

Product Data
Clone Name	2E8
Applications	ELISA, FC, WB
Recommend Dilution	ELISA. Western blot: 1/500-1/2000, recommended starting dilution is 1/1000. Flow Cytometry.
Reactivity	Human, Mouse
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant human α-Crystallin B (1-175 aa) purified from E. coli
Specificity	The antibody recognizes Human and Mouse Alpha-Crystallin B. Other species not tested.
Formulation	PBS, pH 7.4 containing 0.02% Sodium Azide and 10% Glycerol State: Purified State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Affinity Chromatography on Protein G
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for up to two weeks or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	crystallin alpha B
Database Link	Entrez Gene 1410 Human UniProt ID P02511
Background	α-Crystallins are composed of two gene products; α-Crystallin A and B, for acidic and basic, respectively. α-Crystallins can be induced by heat shock and are members of the small heat shock protein (sHSP also known as the HSP20). They act as molecular chaperones and hold them in large soluble aggregates. These heterogeneous aggregates consist of 30-40 subunits; the α-Crystallin A and B subunits have a 3:1 ratio, respectively. Two additional functions of α-crystallins are an autokinase activity and participation in the intracellular architecture. α-Crystallin B is expressed widely in many tissues and organs and occurs in many neurological diseases.
Synonyms	Alpha(B)-crystallin, CRYAB, Heat shock protein beta-5, Renal carcinoma antigen NY-REN-27, HspB5
Reference Data

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