NCR1 Mouse Monoclonal Antibody [Clone ID: n1D9]

Specifications

Product Data
Clone Name	n1D9
Applications	ELISA, FC
Recommend Dilution	ELISA. Flow Cytometry. The antibody has been tested by immunofluorescent staining with flow cytometric analysis and by Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Note: this product is routinely tested on peripheral blood mononuclear cells (PBMCs) or natural killer (Nk) cells.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant human NKp46 (22-255aa) purified from E. coli.
Specificity	This antibody reacts to CD335.
Formulation	PBS, pH 7.4 containing 0.02% Sodium Azide and 10% Glycerol State: Purified State: Liquid ascitic fluid
Purification	Protein-G affinity chromatography
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for up to two weeks or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	natural cytotoxicity triggering receptor 1
Database Link	Entrez Gene 9437 Human UniProt ID O76036
Background	A natural cytotoxicity receptor (NCR), NKp46, is a glycoprotein that has two extracellular Ig-like domains followed by a ~40 residue stalk resion, a type I transmembrane domain, and a short cytoplasmic tail. NKp46 has been shown to represent a novel NK cell-specific molecule involved in human NK cell activation. The natural cytotoxicity receptors (NCRs) are a recently characterized family of Ig-like activation receptors that appear to be major triggering receptors in tumor cell recognition. NKp46 has been implicated in NK cell-mediated lysis of several autologous tumor cells and pathogen-infected cell lines.
Synonyms	NCR1, LY94, NKp46
Reference Data

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