CD5 Rat Monoclonal Antibody [Clone ID: YKIX322.3]

CAT#: SM410R

CD5 rat monoclonal antibody, clone YKIX322.3, PE



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CNY 8,374.00


货期*
4周

规格
    • 100 ug

Product images

Specifications

Product Data
Clone Name YKIX322.3
Applications FC
Recommend Dilution Flow Cytometry.
Reactivity Canine
Host Rat
Clonality Monoclonal
Immunogen Concanavilin A activated canine peripheral blood cells. Spleen cells from immunised DA rat were fused with cells of the rat Y3/A1.2.3 myeloma cell line.
Specificity This antibody recognises a 67kD cell surface glycoprotein expressed on the surface of T-cells. Clone YKIX322.3 was clustered as CD5 in the first canine leucocyte antigen workshop.
Formulation PBS, pH 7.4 containing 0.09% Sodium Azide and 1% Bovine Serum Albumin
Label: PE
State: Lyophilized purified IgG
Label: R. Phycoerythrin (RPE)
Reconstitution Method Restore with 1.0 ml distilled water
Concentration lot specific
Purification Affinity chromatography on Protein G
Conjugation PE
Storage Condition Prior to and following reconstitution store the antibody at 2-8°C.
DO NOT FREEZE!
This product is photosensitive and should be protected from light.
Background CD5 is a 55kDa T lymphocyte single chain transmembrane glycoprotein. It is present on all mature T lymphocytes, on most thymocytes and on many T cell leukemias and lymphomas. It reacts with a subpopulation of activated B cells. CD5/Lyt1 antigen is a monomeric type I transmembrane glycoprotein expressed on thymocytes, T lymphocytes, and a subset of B lymphocytes, but not on natural killer (NK) cells. It has been identified as the major ligand of the B cell antigen CD72. The frequency of CD5+ B cells exhibits strain dependent variation, and the phenotypic, anatomical, functional, developmental, and pathological characteristics of the CD5+ B cells suggest that they may represent a distinct lineage, known as B1 cells. Binding of CD5 on the T cell surface can augment alloantigen or mitogen induced lymphocyte proliferation and induces increased cytosolic free calcium, IL2 secretion, and IL2R expression. It has been proposed that CD5 negatively regulates signal transduction mediated by the T cell and B cell receptors.
Synonyms LEU1, LEU-1, Ly-1, Lyt-1, Lymphocyte antigen T1/Leu-1, T-cell surface glycoprotein CD5
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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