CD8A Mouse Monoclonal Antibody [Clone ID: MEM-31]

Specifications

Product Data
Clone Name	MEM-31
Applications	FC
Recommend Dilution	Flow Cytometry: Human blood cells using 20 µl reagent / 100 µl whole blood or 106 cells in a suspension. Does not work in Immunohistochemistry on formalin fixed cells or Western blot.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Crude thymus membrane fraction
Specificity	The antibody recognizes a conformationally-dependent epitope of CD8 antigen.
Formulation	Phosphate buffered saline (PBS) containing 15 mM Sodium Azide Label: FITC State: Liquid purified Ig fraction Label: Conjugated with Fluorescein isothiocyanate under optimum conditions. The reagent is free of unconjugated and adjusted for direct use.
Conjugation	FITC
Storage Condition	Store the antibody at 2-8°C. DO NOT FREEZE. This product is photosensitive and should be protected from light.
Gene Name	CD8a molecule
Database Link	Entrez Gene 925 Human UniProt ID P01732
Background	The CD8 T cell coreceptor (monomer approx. 32-34 kDa) is expressed as ab heterodimer on majority of MHC I-restricted conventional T cells and thymocytes and as aa homodimer on subsets of memory T cells, intraepithelial lymphocytes, NK cells and dendritic cells. Regulation of CD8b level on T cell surface seems to be an important mechanism to control their effector function. Assembly of CD8 a-b but not a-a dimers is connected with formation or localization to the lipid rafts. Recruiting triggered TCR complexes to these membrane microdomains as well as affinity of TCR to MHC I is modulated by CD8, thereby affecting the functional diversity of the TCR signaling.
Synonyms	CD8 alpha chain, CD8A, MAL
Reference Data
Protein Families	Adult stem cells, Druggable Genome, ES Cell Differentiation/IPS, Secreted Protein, Transmembrane
Protein Pathways	Antigen processing and presentation, Cell adhesion molecules (CAMs), Hematopoietic cell lineage, Primary immunodeficiency, T cell receptor signaling pathway

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.