CD59 Mouse Monoclonal Antibody [Clone ID: MEM-129]

Specifications

Product Data
Clone Name	MEM-129
Applications	FC, FN
Recommend Dilution	Flow Cytometry: 2-8 µg/ml. Functional Studies: The antibody activates T-cells.
Reactivity	Human, Porcine
Host	Mouse
Clonality	Monoclonal
Immunogen	Human peripheral blood lymphocytes
Specificity	The antibody MEM-129 reacts with CD59 (Protectin).
Formulation	Tris buffered saline (TBS), pH 8.0 State: Azide Free State: Liquid purified Ig fraction (> 95% pure by SDS-PAGE)
Concentration	lot specific
Purification	Thiophilic Adsorption-Affinity Chromatography and Size-Exclusion Chromatography
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C. DO NOT FREEZE! Should this product contain a precipitate we recommend microcentrifugation before use.
Gene Name	CD59 molecule
Database Link	Entrez Gene 966 Human UniProt ID P13987
Background	CD59 (Protectin) is a small (18-20 kDa) GPI-anchored ubiquitously expressed inhibitor of the membrane attack complex (MAC). It is thus the key regulator that preserves the autologous cells from terminal effector mechanism of the complement cascade. CD59 associates with C5b-8 complex and thereby counteracts appropriate formation of cytolytic pore within the plasma membrane. CD59 is also an low-affinity ligand of human CD2 and causes T cell costimulation.
Synonyms	MAC-inhibitory protein, Protectin, MEM43 antigen, MIC11, MIN1, MIN2, MIN3, MSK21, MACIF, MAC-IP, MIRL, HRF20, HRF-20
Reference Data

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