SIT (SIT1) Mouse Monoclonal Antibody [Clone ID: SIT-01]

Specifications

Product Data
Clone Name	SIT-01
Applications	FC
Recommend Dilution	Flow cytometry (1/50, intracellular staining).
Reactivity	Human, Mouse
Host	Mouse
Clonality	Monoclonal
Immunogen	Bacterially produced recombinant intracellular fragment of human SIT
Specificity	The antibody reacts with SHP2-interacting transmembrane adaptor protein (SIT) expressed exclusively in lymphoid organs.
Formulation	Phosphate buffered saline (PBS) containing 15 mM sodium azide and 0.2% (w/v) high-grade protease free Bovine Serum Albumin (BSA) as a stabilizing agent Label: PE State: Liquid purified Ig fraction Label: Conjugated with R-Phycoerythrin under optimum conditions. The conjugate is purified by size-exclusion chromatography.
Concentration	lot specific
Conjugation	PE
Storage Condition	Store the antibody at 2 - 8 °C. DO NOT FREEZE! This product is photosensitive and should be protected from light.
Gene Name	signaling threshold regulating transmembrane adaptor 1
Database Link	Entrez Gene 27240 Human UniProt ID Q9Y3P8
Background	SIT (SHP2-interacting transmembrane adaptor protein) is expressed exclusively in lymphoid organs and acts either as a positive or as a negative regulatory element in T cell activation and in T cell development. Binding to Grb2 plays a pivotal role in signal transduction. Hubener et al. (2001) determined that the SIT gene contains 5 exons and spans 1.8 kb of genomic DNA. The SIT promoter demonstrated strong transcriptional activity and potential binding sites for both ubiquitous and lymphoid-specific transcription factors.
Synonyms	gp30/40; MGC125908; MGC125909; MGC125910; RP11-331F9.5; SIT
Reference Data
Protein Families	Transmembrane

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