CD9 Mouse Monoclonal Antibody [Clone ID: MEM-61]

Specifications

Product Data
Clone Name	MEM-61
Applications	FC, FN, IHC, IP, WB
Recommend Dilution	Immunohistochemistry on Paraffin Sections: 20 μg/ml. Positive tissue: Prostate. Flow Cytometry: 5 μg/ml. Immunoprecipitation. Western blot: 2-4 µg/ml (Non Reducing Conditions). Functional Application: The antibody induces FcgR-dependent platelet activation / aggregation.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Pre-B cell line NALM-6
Specificity	The antibody recognizes an epitope on second extracellular domain (EC2) of CD9 antigen, a 24 kDa single transmembrane polypeptide expressed on platelets, monocytes, pre-B lymphocytes, granulocytes and activated T lymphocytes.
Formulation	Phosphate buffered saline (PBS), pH~7.4 with 15 mM Sodium Azide as preservative State: Purified State: Liquid purified Ig fractionn (> 95% pure by SDS-PAGE)
Concentration	lot specific
Purification	Affinity Chromatography on Protein A
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C. DO NOT FREEZE!
Gene Name	CD9 molecule
Database Link	Entrez Gene 928 Human UniProt ID P21926
Background	CD9 belongs to proteins of tetraspanin family that orchestrate cholesterol-associated tetraspanin-enriched signaling microdomains within the plasma membrane, forming complexes with each other as well as with integrins, membrane-anchored growth factors and other proteins. CD9 is involved in cell motility, osteoclastogenesis, neurite outgrowth, myotube formation, and sperm-egg fusion, plays roles in cell attachment and proliferation and is necessary for association of heterologous MHC II molecules on the dendritic cell plasma membrane which is important for effective T cell stimulation. CD9 is also considered as metastasis suppressor in solid tumors.
Synonyms	MIC3, TSPAN29, GIG2, p24, Tetraspanin-29, 5H9 antigen
Reference Data

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