Integrin beta 1 (ITGB1) Mouse Monoclonal Antibody [Clone ID: MEM-101A]

CAT#: SM3016R

Integrin beta 1 (ITGB1) mouse monoclonal antibody, clone MEM-101A, PE



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CNY 4,340.00


货期*
5周

规格
    • 100 Tests

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Specifications

Product Data
Clone Name MEM-101A
Applications FC
Recommend Dilution Flow Cytometry: 20 µl reagent / 100 µl of whole blood or 106 cells in a suspension.
The content of a vial (2 ml) is sufficient for 100 tests.
Reactivity Human, Porcine, Canine
Host Mouse
Clonality Monoclonal
Immunogen Raji Burkitt's lymphoma cell line
Specificity The antibody MEM-101A reacts with CD29 (integrin beta-1 chain), a 130 kDa single chain type I glycoprotein expressed as a heterodimer (non-covalently associated with the integrin alpha subunits 1-6). CD29 is broadly expressed on majority of hematopoietic and non-hematopoietic cells (leukocytes, platelets, fibroblasts, endothelial cells, epithelial cells and mast cells).
Formulation Phosphate buffered saline (PBS) solution containing 15mM sodium azide
Label: PE
State: Liquid purified IgG fraction
Label: Conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use.
Purification Size-Exclusion Chromatography
Conjugation PE
Storage Condition Store the antibody in the dark at 2-8°C.
Do Not Freeze!
Avoid prolonged exposure to light.
Gene Name integrin subunit beta 1
Background CD29 (beta1 integrin subunit, GPIIa) forms non-covalently linked heterodimers with at least 6 dibberent alpha chains (alpha1-alpha6, CD49a-f) determining the binding properties of beta1 (VLA) integrins. These integrins mediate cell adhesion to collagen, fibronectin, laminin and other extracellular matrix (ECM) components. This interaction hinders cell death, whereas disruption of anchorage to ECM leads to apoptosis. Decreased expression of most beta1 integrins correlates with acquiring multidrug resistance of tumour cells during selection in presence of antitumour drug. In platelets, translocation of intracellular pool of beta1 integrins to the plasma membrane following thrombin stimulation. These integrins are also up-regulated in leukocytes during emigration and extravascular migration and appear to be critically involved in regulating the immune cell trafficking from blood to tissue, as well as in regulating tissue damage and disease symptoms related to inflammatory bowel disease. Through a beta1 integrin-dependent mechanism, fibronectin and type I collagen enhance cytokine secretion of human airway smooth muscle in response to IL-1beta.
Synonyms Fibronectin receptor subunit beta, Integrin VLA-4 subunit beta, ITGB1, FNRB, MDF2, MSK12
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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