CD2 Mouse Monoclonal Antibody [Clone ID: MEM-65]

Specifications

Product Data
Clone Name	MEM-65
Applications	FC
Recommend Dilution	Flow Cytometry analysis of blood cells using 20 μl reagent / 100 μl of whole blood or 10e6 cells in a suspension. The content of a vial (2 ml) is sufficient for 100 tests.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Human peripheral T cells
Specificity	This antibody recognizes an unique epitope of CD2, a 50 kDa glycoprotein present on the human peripheral blood T-lymphocytes and NK cells; also expressed by all thymocytes.
Formulation	Phosphate buffered saline (PBS) containing 15 mM sodium azide and 0.2 % (w/v) high-grade protease free Bovine Serum Albumin (BSA) as a stabilizing agent Label: PE State: Liquid purified Ig fraction Label: Conjugated with R-Phycoerythrin under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use
Conjugation	PE
Storage Condition	Store the antibody at 2 - 8 °C. DO NOT FREEZE! Centrifuge vial before opening. This product is photosensitive and should be protected from light.
Gene Name	CD2 molecule
Database Link	Entrez Gene 914 Human UniProt ID P06729
Background	CD2 belongs to T lymphocyte glycoproteins of immunoglobulin superfamily. Its interaction with CD58 stabilizes adhesion between T cells and antigen presenting or target cells. Relatively low affinity of CD2 to CD58 (as measured in solution) is compensated within the two-dimensional cell-cell interface to provide tight adhesion. Morover, T cell activation induces increased CD2 expression and its lateral mobility, making easier contact between CD2 and CD58. Subsequently, T cell activation causes fixation of CD58-CD2 at sites of cell-cell contact, thereby strengthening intercellular adhesion. CD2 deficiency reduces intestinal inflammation and helps to control infection.
Synonyms	SRBC, Erythrocyte receptor, LFA-2, LFA-3 receptor, Rosette receptor
Reference Data

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.