Ptprc Mouse Monoclonal Antibody [Clone ID: OX-1]

Specifications

Product Data
Clone Name	OX-1
Applications	FC
Recommend Dilution	Flow Cytometry: Use 10 µl of neat antibody to label 10e6 cells in 100 µl. (This product is routinely tested in flow cytometry on rat splenocytes).
Reactivity	Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Rat thymocyte membrane glycoproteins.
Specificity	This antibody recognizes CD45. OX-1 reacts with all forms of CD45 expressed by all haematopoietic cells, except erythrocytes.
Formulation	PBS, pH 7.4 Label: PE State: Lyophilized purified IgG fraction Stabilizer: 1% BSA, 5% Sucrose Preservative: 0.09% Sodium Azide Label: Phycoerythrin (RPE)
Reconstitution Method	Restore with 1 ml distilled water.
Conjugation	PE
Storage Condition	Store undiluted Prior to and following reconstitution at 2-8°C. DO NOT FREEZE. This product is photosensitive and should be protected from light.
Gene Name	protein tyrosine phosphatase, receptor type, C
Database Link	Entrez Gene 24699 Rat UniProt ID P04157
Background	CD45 is a family of single chain transmembraneous glycoproteins consisting of at least four isoforms (220, 205, 190, 180 kDa) which share a common large intracellular domain. Their extracellular domains are heavily glycosylated. The different isoforms are produced by alternative messenger RNA splicing of three exons of a single gene on chromosome 1. CD45 is expressed on cells of the human hematopoietic lineage (including hematopoietic stem cells) with the exception of mature red cells. It is not detected on differentiated cells of other tissues. It is likely that CD45 plays an important role in signal transduction, inhibition or upregulation of various immunological functions. Antibodies recognising a common epitope on all of the isoforms are termed CD45 whilst those recognising only individual isoforms are termed CD45RA or CD45RO etc.
Synonyms	PTPRC, Leukocyte common antigen, L-CA, T200
Reference Data

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