Cd2 Mouse Monoclonal Antibody [Clone ID: OX-34]

Specifications

Product Data
Clone Name	OX-34
Applications	FC, IHC, IP
Recommend Dilution	Immonoprecipitation. Flow Cytometry: Use 10 µl of 1/50 diluted antibody to label 10e6 cells in 100 µl. Immunohistochemistry on Frozen and Paraffin Sections.
Reactivity	Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Activated Rat T helper cells. Spleen cells from immunised BALB/c mice were fused with cells of the mouse NS1 myeloma cell line.
Specificity	This antibody recognizes the CD2 cell surface antigen, a 50-54kD glycoprotein expressed by thymocytes and mature T cells.
Formulation	PBS, pH 7.4 containing 0.09% Sodium Azide State: Purified State: Liquid purified IgG fraction.
Concentration	lot specific
Purification	Affinity Chromatography on Protein G.
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	Cd2 molecule
Database Link	Entrez Gene 497761 Rat UniProt ID P08921
Background	CD2 is a surface antigen of the human T lymphocyte lineage that is expressed on all peripheral blood T cells. It is one of the earliest T cell markers, being present on more than 95% of thymocytes; it is also found on some natural killer cells but not on B lymphocytes. CD2 interacts with lymphocyte function associated antigen (LFA3) and CD48/BCM1 to mediate adhesion between T cells and other cell types. CD2 is implicated in the triggering of T cells, the cytoplasmic domain is implicated in the signaling function. It is useful for the identification of lymphomas and leukaemias of T cell origin.
Synonyms	SRBC, Erythrocyte receptor, LFA-2, LFA-3 receptor, Rosette receptor
Reference Data

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