CD321 / JAM1 Rat Monoclonal Antibody [Clone ID: H202-106]

Specifications

Product Data
Clone Name	H202-106
Applications	FC, IHC, IP
Recommend Dilution	Flow Cytometry: Use 10 µl of neat-1/5 diluted antibody to label 106 cells in 100 µl.
Reactivity	Mouse
Host	Rat
Clonality	Monoclonal
Immunogen	MTE1/MTE2 stromal cell lines. Cells from immunised Lou rats were fused with cells of the X63 mouse myeloma cell line.
Specificity	This antibody recognizes CD321, which is also known as Junctional Adhesion Molecule 1 (JAM-1).
Formulation	PBS, pH 7.4 Label: Biotin State: Liquid purified IgG fraction from Tissue Culture Supernatant Stabilizer: 1% BSA Preservative: 0.09% Sodium Azide
Concentration	lot specific
Purification	Affinity Chromatography on Protein G
Conjugation	Biotin
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	F11 receptor
Database Link	Entrez Gene 16456 Mouse UniProt ID O88792
Background	CD321 is a 32-41kD glycoprotein, which shares similarities with related proteins JAM-2 and JAM-3. CD321 is a multifunctional protein that is primarily expressed by platelets, endothelial and epithelial cells. The CD321 protein co-localises with tight junction molecules in both epithelial and endothelial cells and plays an important role in the regulation of junctional integrity and permeability. In addition, CD321 is a ligand for the integrin LFA-1 and is also involved in the transmigration of leucocytes.
Synonyms	JAM-A, Platelet F11 receptor, F11R, JCAM, PAM1
Reference Data

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