DC SIGN (CD209) Mouse Monoclonal Antibody [Clone ID: MR-1]

Specifications

Product Data
Clone Name	MR-1
Applications	FC, FN, IF
Recommend Dilution	Flow cytometry: Use 10 µl to label 10e6 cells in 100ml. Immunofluorescence. Functional assays.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Immature myeloid monocyte-derived dendritic cells (MDDCs)
Specificity	This antibodies recognises human DC-specific ICAM-3 grabbing nonintegrin (DC-SIGN), a 45kD C-type lectin that binds ICAM-3 also known as CD209.
Formulation	PBS, pH 7.4, without preservatives or stbilizers State: Low Endotoxin State: Liquid purified IgG fraction
Concentration	lot specific
Purification	Protein G affinity chromatography
Conjugation	Unconjugated
Storage Condition	Store undiluted (in aliquots) at -20°C. Avoid repeated freezing and thawing.
Gene Name	CD209 molecule
Database Link	Entrez Gene 30835 Human UniProt ID Q9NNX6
Background	CD209 is primarily expressed on a population of immature dendritic cells in peripheral tissues and on immature myeloid monocyte-derived DC's in vitro. CD209 is involved in dendritic cell (DC) migration and the initial interaction between DC's and naive T lymphocytes. CD209 also binds HIV-1 gp120 and plays a key role in the dissemination of HIV-1 by DC's. Clone MR-1 is reported to partially block the functional activity of DC-SIGN(2).
Synonyms	DCSIGN1, DCSIGN, DC-SIGN1, CLEC4L, Dendritic Cell Marker
Reference Data

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