hCG beta (CGB3) (beta 2 epitope) Mouse Monoclonal Antibody [Clone ID: INN-hCG-22]

Specifications

Product Data
Clone Name	INN-hCG-22
Applications	ELISA, IHC, WB
Recommend Dilution	Immunohistochemistry on paraffin sections. ELISA: 1:100 - 1:500. Western Blot: Non-reducing conditions.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	hCG. Spleen cells from an immunised BALB/c mouse were fused with cells of the mouse myeloma cell line P3 - NS1/1 - Ag 4.1.
Specificity	This antibody shows strong reaction in RIA with hCG and b-hCG with some reactivity on hLH (12%) and b-hLH (34%). No reaction with hFSH, hTSH, a-hCG and a-hLH.
Formulation	Containing 0.09% Sodium Azide State: Purified State: Liquid purified IgG
Concentration	lot specific
Purification	Ion exchange chromatography
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	chorionic gonadotropin beta subunit 3
Database Link	Entrez Gene 1082 Human UniProt ID P0DN86
Background	Human chorionic gonadotropin (hCG) is a glycoprotein hormone produced by trophoblastic cells of the placenta beginning 10 to 12 days after conception. Maintenance of the fetus in the first trimester of pregnancy requires the production of hCG, which binds to the corpus luteum of the ovary which is stimulated to produce progesterone which in turn maintains the secretory endometrium. hCG is present only in trace amounts in non pregnant urine and sera. It rises sharply during pregnancy. HCG is composed of two non identical, non covalently linked polypeptide chains designated as the a and b subunits. The a subunit of HCG is nearly identical to that of thyroid stimulating hormone (TSH), follicle stimulating hormone (FSH) and luteinizing hormone (LH). A germ cell tumor which is positive for cytokeratin, placental alkaline phosphatase (PLAP) and HCG but negative for EMA and AFP is probably a choriocarcinoma.
Synonyms	Choriogonadotropin subunit beta, CGB, CGB3, beta hCG, hCG-beta
Reference Data

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