Junctional Adhesion Molecule 1 (F11R) Mouse Monoclonal Antibody [Clone ID: M.Ab.F11]
CAT#: SM2040PS
Junctional Adhesion Molecule 1 (F11R) mouse monoclonal antibody, clone M.Ab.F11, Purified
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CNY 7,800.00
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Specifications
Product Data | |
Clone Name | M.Ab.F11 |
Applications | ELISA, FC, FN, IF, IHC, IP, WB |
Recommend Dilution | Flow Cytometry (Ref.4,8): Antibody M.Ab. F11 stains the extracellular domain of JAM-A protein name. Cells were incubated with 5 µg/ml of mAb in 0.1%BSA/PBS. As Negative Control an isotype-matched antibody was used (Ref.4): The typical starting working dilution is 1/50. Functional Assays (Ref.1-3): Antibody M.Ab. F11 functions as anagonist resulting in platelet aggregation at concentrations of approximately 5 µg/ml (Ref.1). Immunoassays (Ref.7). Immunofluorescence (Ref.5,6). Imunoprecipitation (Ref.4). Immunohistochemistry on Paraffin Sections (Ref.6): The typical starting working dilution is 1/50. Western blot (Ref.1,2,4): A non-reduced and reduced sample treatment and SDS-Page was used. The band sizes iare 32 and35kDa (Ref.1). The typical starting working dilution is 1/50. |
Reactivity | Human |
Host | Mouse |
Clonality | Monoclonal |
Immunogen | Human platelet membranes |
Specificity | The monoclonal antibody M.Ab.F11 recognizes Junctional Adhesion Molecule-A (JAM-A) also known as the Human platelet F11-Receptor (F11R) or JAM-1. |
Formulation | PBS State: Purified State: Liquid 0.2 µm filtered Ig fraction Stabilizer: 0.1% BSA |
Concentration | lot specific |
Purification | Protein G Chromatography |
Conjugation | Unconjugated |
Storage Condition | Store undiluted at 2-8°C. DO NOT FREEZE! |
Gene Name | F11 receptor |
Database Link | |
Background | JAM-A is a surface glycoprotein duplex (32 and 35 kDa) belongingto the immunoglobulin superfamily found on the surface of human platelets and at intercellular junctions of endothelial cells and epithelial cells. JAM-A belongs together with JAM-C (JAM-2) and JAM-B (VE-JAM or JAM-3) to a family of adhesion proteins with a V-C2 immunoglobulin domain organization. JAM-A plays an important role in tight junctions where it is involved in cell-to-cell adhesion through homophilic interactions. It co-distributes with other tight junction components such as ZO-1, 7H6 antigen, cingulin and occludin. Moreover, JAM-A plays a role in platelet aggregation, secretion, adhesion, spreading. |
Synonyms | JAM-A, Platelet F11 receptor, F11R, JCAM, PAM1 |
Reference Data |
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