Granzyme B (GZMB) Mouse Monoclonal Antibody [Clone ID: GB11]

Specifications

Product Data
Clone Name	GB11
Applications	ELISA, FC, IF, IHC, IP
Recommend Dilution	ELISA: 2-5 µg/ml. Immunoprecipitation. Immunofluorescence. Immunohistochemistry on Frozen Sections. Flow Cytometry: Use 10 µl of 1/10-1/100 diluted antibody to label 106 cells or 100 µl whole blood (Membrane permeabilisation is required).
Reactivity	Chimpanzee, Human, Monkey
Host	Mouse
Clonality	Monoclonal
Immunogen	Purified human Granzyme B.
Specificity	This antibody recognises the serine protease Granzyme B. This antibody has been reported to function as a Capture reagent in ELISA assays for soluble Granzyme B in conjunction with biotin conjugated clone GB10 (SM1805B) as detection reagent.
Formulation	Tris buffered saline containing 0.09% Sodium Azide as preservative State: Purified State: Liquid purified IgG fraction
Concentration	lot specific
Purification	Affinity chromatography on Protein A
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	granzyme B
Database Link	Entrez Gene 3002 Human UniProt ID P10144
Background	Ganzyme B is important in the induction of apoptosis in target cells by cytolytic lymphocytes (CTLs). Granzyme B plays a key role in the induction of apoptosis by CTLs. After delivery to the target cell, Granzyme B activates the cascade of caspases that finally results in cell death.
Synonyms	Granzyme-2, CGL1, CTSGL1, CSPB, CTLA1, CTLA-1, GRB, SECT, Fragmentin-2
Reference Data

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