CD31 (PECAM1) Mouse Monoclonal Antibody [Clone ID: WM59]

Specifications

Product Data
Clone Name	WM59
Applications	FC, IP
Recommend Dilution	Flow Cytometry: Use 10 µl of 1/50-1/100 diluted antibody to label 10e6 cells in 100 µl. Immunoprecipitation.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Specificity	This antibody clone WM59 recognizes the Human CD31 antigen, a ~130kD single pass type I transmembrane glycoprotein bearing six C2 immunoglobulin domains. The binding epitope for Mouse anti Human CD31, clone WM59 has been mapped to the Ig-like domain 2 (Fawcett et al. 1995).
Formulation	PBS, pH 7.4 State: Purified State: Liquid purified IgG fraction from Tissue Culture Supernatant Preservative: 0.09% Sodium Azide
Concentration	lot specific
Purification	Affinity Chromatography on Protein G
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	platelet and endothelial cell adhesion molecule 1
Database Link	Entrez Gene 5175 Human UniProt ID P16284
Background	CD31, also known as platelet endothelial cell adhesion molecule 1 (PECAM1), is a type I integral membrane glycoprotein and a member of the immunoglobulin superfamily of cell surface receptors. It is constitutively expressed on the surface of endothelial cells, and concentrated at the junction between them. It is also weakly expressed on many peripheral lymphoid cells and platelets. CD31 has been used to measure angiogenesis in association with tumor recurrence. Other studies have also indicated that CD31 and CD34 can be used as markers for myeloid progenitor cells and recognize different subsets of myeloid leukemia infiltrates (granular sarcomas). CD31 is a 130kD glycoprotein expressed by platelets, endothelial cells, granulocytes and some lymphocytes.
Synonyms	PECAM-1, EndoCAM, GPIIA'
Reference Data

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