PLP1 (C-term) Mouse Monoclonal Antibody [Clone ID: plpc1]

Specifications

Product Data
Clone Name	plpc1
Applications	FC, IF, IHC, WB
Recommend Dilution	Western blot.  Flow Cytometry.  Immunofluorescence.  Immunohistochemistry on Frozen Sections.  Immunohistochemistry on Paraffin Sections: 10 µg/ml after heat-induced antigen retrieval.
Reactivity	Bovine, Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Synthetic peptide CGRGTKF corresponding to C-terminal region of Myelin Proteolipid Protein. Spleen cells from immunised BALB/c mice were fused with cells of the mouse SP2/0 myeloma cell line.
Specificity	This antibody recognizes Myelin Proteolipid protein (PLP) in many Mammalian species. This antibody also recognizes DM20.
Formulation	PBS State: Purified State: Liquid purified IgG fraction Preservative: 0.09% Sodium Azide
Concentration	lot specific
Purification	Affinity Chromatography on Protein A from Tissue Culture Supernatant
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Database Link	Entrez Gene 281410 Bovine UniProt ID P04116
Background	Myelin proteins are associated with the central nervous system (CNS) and play a role in the compaction, stabilization, and maintenance of myelin sheaths, as well as in oligodendrocyte development and axonal survival. The proteolipid protein (PLP) and its splice variant DM20 are the predominant myelin proteins in the CNS. PLP is also one of the most extensively studied myelin proteins because of the prevelance of PLP mutations amongst humans and animals. Such mutations can lead to abnormal myelin formation resulting in conditions such as X-linked Pelizaeus-Merzbacher disease and spastic paraplegia type 2. PLP encodes the major protein components of compact CNS myelin and mutations in the PLP gene can lead to severe dysmyelinating disease.
Synonyms	Myelin proteolipid protein, Lipophilin, PLP
Reference Data

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