HLAB (HLA-B) Mouse Monoclonal Antibody [Clone ID: BB7.1]

Specifications

Product Data
Clone Name	BB7.1
Applications	FC
Recommend Dilution	Flow Cytometry: Use 10 µl of neat-1/10 diluted antibody to label 1x106 cells in 100 µl whole blood.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Papain solubilized HLA-B7 antigen.
Specificity	This antibody recognises the Human HLA-B7 antigen and does not cross-react with HLA-B27 or other related HLA antigens. It can be used to distinguish true HLA-B27 positives from false HLA-B27 positives (i.e. HLA-B7 positive) in the investigation of such diseases as ankylosing spondylitis and anterior uveitis.
Formulation	PBS, pH 7.4 Label: FITC State: Liquid purified IgG fraction from Tissue Culture Supernatant Stabilizer: 1% BSA Preservative: 0.09% Sodium Azide Label: Fluorescein Isothiocyanate Isomer 1
Concentration	lot specific
Purification	Affinity Chromatography on Protein G
Conjugation	FITC
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.  This product is photosensitive and should be protected from light. Should this product contain a precipitate we recommend micro-centrifugation before use. Avoid repeated freezing and thawing.
Gene Name	major histocompatibility complex, class I, B
Database Link	Entrez Gene 3106 Human UniProt ID P01889
Background	HLA B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta 2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa. Hundreds of HLA B alleles have been described.  The HLA B gene is part of the human HLA complex on chromosome 6 and there are a large number of variant alleles of this gene.
Synonyms	HLAB, MHC class I antigen B7
Reference Data

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