FGF2 Mouse Monoclonal Antibody [Clone ID: MC-GF1]

Specifications

Product Data
Clone Name	MC-GF1
Applications	ELISA, IHC, WB
Recommend Dilution	Immunohistochemistry on frozen and paraffin embedded sectionssections. ELISA. Western blotting.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant human bFGF
Specificity	This antibody recognises basic fibroblast growth factor (bFGF). The antibody binds strongly to bFGF attached to proteoglycans, but is competitively displaced by heparin. Not suitable for detecting bFGF bound to cell surface receptors.
Formulation	PBS containing 0.09% sodium azide State: Purified State: Liquid purified IgG fraction
Concentration	lot specific
Purification	Protein G chromatography
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	fibroblast growth factor 2
Database Link	Entrez Gene 2247 Human UniProt ID P09038
Background	FGF basic (FGF2) is a member of the fibroblast growth factor (FGF) family. FGF family members bind heparin and possess broad mitogenic and angiogenic activities. FGF2 is involved in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. FGF2 mRNA contains multiple polyadenylation sites, and is alternatively translated from AUG and non-AUG (CUG) initiation codons resulting in five different isoforms with distinct properties. The CUG-initiated isoforms are localized in the nucleus and are responsible for the intracrine effect, whereas, the AUG-initiated form is mostly cytosolic and is responsible for the paracrine and autocrine effects of this FGF.
Synonyms	FGFB, Heparin-binding growth factor 2, Fibroblast growth factor 2 (basic), BFGF, HBGF-2, HBGF2
Reference Data

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