IL3RA Mouse Monoclonal Antibody [Clone ID: 6H6]

Specifications

Product Data
Clone Name	6H6
Applications	FC, IHC, IP, WB
Recommend Dilution	Flow Cytometry. Immunoprecipitation. Western blot. Immunohistochemistry on Frozen Sections.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	IL3 receptor alpha chain expressed on the surface of transiently transfected COS cells
Specificity	This antibody recognizes CD123 (interleukin 3 receptor alpha), a 60-70 kDa transmembrane protein expressed by myeloid precursors, megakaryocytes, macrophages, dendritic cells, mast cells, basophils, and some B cells. This antibody does not inhibit IL-3 binding to its receptor.
Formulation	Phosphate buffered saline (PBS) State: Purified State: Liquid purified Ig fraction (> 95% pure by SDS-PAGE) Preservative: 15 mM sodium azide, approx. pH 7.4
Concentration	lot specific
Purification	Affinity Chromatography on Protein A
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C. DO NOT FREEZE!
Gene Name	interleukin 3 receptor subunit alpha
Database Link	Entrez Gene 3563 Human UniProt ID P26951
Background	CD123 is the alpha chain of interleukin 3 receptor (IL-3R alpha). This subunit heterodimerizes with the interleukin 3 receptor beta chain (CD131), which is shared with other receptors. CD123 interacts with IL-3 specifically, but with low affinity, and association with the beta subunit confers high affinity binding to the receptor heterodimer. Both chains are required for signaling, but receptor activation and signal transduction depend on IL-3 binding to CD123 as the initial step.
Synonyms	Interleukin-3 receptor subunit alpha, IL-3R-alpha, IL3 receptor alpha
Reference Data

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