VCAM1 Mouse Monoclonal Antibody [Clone ID: 1.G11B1]

Specifications

Product Data
Clone Name	1.G11B1
Applications	ELISA, FC, IHC, IP
Recommend Dilution	ELISA. Immunoprecipitation. Flow Cytometry (1/10-1/50). Immunohistochemistry on Frozen Tissues. Functional Assays: This antibody inhibits cellular adhesion mediated by VCAM-1. Removal of Sodium Azide is recommended prior to use.
Reactivity	Human, Monkey, Porcine
Host	Mouse
Clonality	Monoclonal
Specificity	This antibody recognises Human VCAM-1, a 110 kD molecule whose ligand is VLA-4. The antigen is expressed on activated endothelial cells and some tissue macrophages, bone marrow fibroblasts and myoblasts. Cross reactivity to Porcine CD106 has been reported.
Formulation	PBS containing 0.09% Sodium Azide as preservative and 0.1% BSA as stabilizer. State: Aff - Purified State: Liquid purified Ig fraction.
Concentration	lot specific
Purification	Affinity Chromatography on Protein A.
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf live: one year from despatch.
Gene Name	vascular cell adhesion molecule 1
Database Link	Entrez Gene 7412 Human UniProt ID P19320
Background	CD106 (known as VCAM1) is important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with the integrins alpha4 beta1 (beta 1 integrin VLA4) and alpha4 beta7 on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/VLA4 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation. VCAM1 is also expressed by several non endothelial cell types including some macrophages, follicular dendritic cells and bone marrow, stromal cells.
Synonyms	V-CAM 1, INCAM-100, L1CAM, VCAM-1
Reference Data

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