CD27 Mouse Monoclonal Antibody [Clone ID: LT27]

Specifications

Product Data
Clone Name	LT27
Applications	FC
Recommend Dilution	Flow Cytometry analysis of human blood cells using 10 µl reagent / 100 µl of whole blood or 106 cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Human peripheral blood lymphocytes
Specificity	This antibody reacts with CD27 (T14), a 50-55 kDa type I transmembrane glycoprotein (member of the TNF-receptor superfamily) expressed on medullary thymocytes, peripheral T lymphocytes, some B lymphocytes and NK cells.
Formulation	Phosphate buffered saline (PBS) solution containing 15mM sodium azide Label: APC State: Liquid Ig fraction Label: Conjugated with cross-linked Allophycocyanin under optimum conditions
Purification	Size-exclusion chromatography
Conjugation	APC
Storage Condition	Store undiluted at 2-8°C. DO NOT FREEZE! This product is photosensitive and should be protected from light.
Gene Name	CD27 molecule
Database Link	Entrez Gene 939 Human UniProt ID P26842
Background	CD27 is a transmembrane 55 kDa protein of the nerve growth factor-receptor family, expressed as a disulfide-linked homodimer on mature thymocytes, peripheral blood T cells and a subpopulation of B cells. Activation of T cells via TCR-CD3 complex results in upregulation of CD27 expression on the plasma membrane as well as in the release of its soluble 28-32 kDa form, sCD27, detected in the plasma, urine or spinal fluid. This sCD27 is an important prognostic marker of acute and chronic B cell malignancies. RgpA, a cystein proteinase, although activating T cells through the protease-activated receptors (PARs), degradates CD27 and counteracts T cell activation mediated by CD27 and its ligand CD70.
Synonyms	TNFRSF7, CD27L receptor, T14
Reference Data

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