CD13 (ANPEP) Mouse Monoclonal Antibody [Clone ID: WM15]

Specifications

Product Data
Clone Name	WM15
Applications	ELISA, FC, FN, IHC, IP
Recommend Dilution	ELISA. Flow Cytometry: 5 µg/ml. Immunoprecipitation. Immunohistochemistry on Frozen Sections. Functional Application: The antibody clone WM15 inhibits infection of cells by Human coronavirus and inhibits aminopeptidase N activity of the CD13 molecule immunoprecipitates.
Reactivity	Human, Primate
Host	Mouse
Clonality	Monoclonal
Immunogen	Human AML cells
Specificity	The antibody recognises the Human CD13 cell surface glycoprotein, a 150 kD molecule expressed by granulocytes and monocytes, and by myeloid leukaemia cells.
Formulation	PBS, pH~7.4 containing 15 mM Sodium Azide as preservative State: Purified State: Liquid purified Ig fraction (> 95% pure by SDS-PAGE)
Concentration	lot specific
Purification	Affinity Chromatography on Protein G
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C. DO NOT FREEZE!
Gene Name	alanyl aminopeptidase, membrane
Database Link	Entrez Gene 290 Human UniProt ID P15144
Background	CD13 is a 150 kDa type II transmembrane zinc-binding ectopeptidase expressed on various cell types. This metalloprotease preferentially catalyzes removal of neutral amino acids from small peptides, thus activating or inactivating bioactive peptides. CD13 has also role in extracellular matrix degradation, antigen processing and signal transduction, is important in inflammatory responses, regulates intercellular contact, cell motility and vascularization. CD13 is involved in protection of leukemic cells against apoptosis and its expression associated with poor prognosis of carcinomas. CD13 functions as an aminopeptidase enzyme and is also a receptor for coronavirus.
Synonyms	Aminopeptidase N, ANPEP, APN, PEPN
Reference Data

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