CD13 (ANPEP) Mouse Monoclonal Antibody [Clone ID: WM15]

Specifications

Product Data
Clone Name	WM15
Applications	FC
Recommend Dilution	Indirect immunofluorescence analysis by Flow cytometry.
Reactivity	Human, Primate
Host	Mouse
Clonality	Monoclonal
Immunogen	Human AML cells
Specificity	This antibody detects CD13 cell surface glycoprotein, a 150 kDa molecule expressed on granulocytes, endothelial cells, epithelial cells and myeloid progenitors.
Formulation	Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4 Label: Biotin State: Liquid purified Ig fraction Label: Conjugated with Biotin-LC-NHS under optimum conditions. The reagent is free of unconjugated biotin.
Concentration	lot specific
Conjugation	Biotin
Storage Condition	Store the antibody at 2 - 8 °C. DO NOT FREEZE!
Gene Name	alanyl aminopeptidase, membrane
Database Link	Entrez Gene 290 Human UniProt ID P15144
Background	CD13 (aminopeptidase N, APN) is a 150 kDa type II transmembrane zinc-binding ectopeptidase expressed on various cell types. This metalloprotease preferentially catalyzes removal of neutral amino acids from small peptides, thus activating or inactivating bioactive peptides. CD13 has also role in extracellular matrix degradation, antigen processing and signal transduction, is important in inflammatory responses, regulates intercellular contact, cell motility and vascularization. CD13 is involved in protection of leukemic cells against apoptosis and its expression associated with poor prognosis of carcinomas.
Synonyms	Aminopeptidase N, ANPEP, APN, PEPN
Reference Data
Protein Families	Druggable Genome, ES Cell Differentiation/IPS, Protease, Transmembrane
Protein Pathways	Glutathione metabolism, Hematopoietic cell lineage, Metabolic pathways, Renin-angiotensin system

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