Cyclin E1 (CCNE1) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, IP, WB
Recommend Dilution	ELISA: 1:2,000. Immunoprecipitation. Western Blot: 1:200 to 1:500.
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Full length synthetic polypeptide corresponding to the human gene sequence.
Specificity	This product was prepared from monospecific antiserum by delipidation and defibrination. Antiserum will specifically react with a 45 kDa Cyclin E protein. No reaction was observed against other related cyclins. Cross reactivity with Cyclin E from other species may also occur.
Formulation	State: Serum State: Liquid serum containing 0.01% Sodium Azide
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store the antibody at -20°C. Avoid repeated freezing and thawing.
Gene Name	cyclin E1
Database Link	Entrez Gene 898 Human UniProt ID P24864
Background	Cyclin E is a regulatory subunit of Cdk2 and controls G1 / S transition during the mammalian cell cycle. Multiple isoforms of Cyclin E are only expressed in tumors but not in normal tissue, suggesting a post transcriptional regulation of Cyclin E. In vitro analyses indicated that these truncated variant isoforms of Cyclin E are able to phosphorylate histone H1. Alterations in the Cyclin E protein have been implicated as indicators of worse prognosis in various cancers.
Synonyms	Cyclin-E1, CCNE1, CCNE
Reference Data

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