TAC1 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC
Recommend Dilution	Immunofluorescence: 1/200-1/400 (IF Microscopy using FITC with overnight incubation at 2-8°C). Immunohistochemistry on Paraffin Embedded and Frozen tissues: 1/400-1/800 (using PAP). Positive Control: Formalin-fixed paraffin sections of Rat colon.
Reactivity	Fish, Human, Porcine, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Substance K / Neurokinin A (Peninsula) conjugated to BSA
Specificity	This antibody reacts with Substance K / Neurokinin A. Absoprtion with 10-100 µg Substance K per ml diluted antiserum abolishes the staining, while Substance P does not.
Formulation	State: Serum State: Lyophilized undiluted Serum.
Reconstitution Method	Dissolve the antiserum in 50-100 µl distilled water, and dilute further in 0.1M PBS with 1% BSA and 0.09% Sodium Azide.
Conjugation	Unconjugated
Storage Condition	Prior to reconstitution store at 2-8°C. Following reconstitution store the antibody at -20°C. Avoid repeated freezing and thawing.
Gene Name	tachykinin precursor 1
Database Link	Entrez Gene 24806 RatEntrez Gene 6863 Human UniProt ID P20366
Background	Neurokinin A/Substance K represents a member of the tachykinin family of peptides. Neurokinin A, which arises by cleavage of the substance P precursor, occurs in neurons in the central and peripheral nervous systems, and is particularly numerous in the gastrointestinal tract. The biological actions of neurokinin A are similar to those of substance P, and include vasodilation and stimulation of smooth muscle contraction.
Synonyms	TAC1, NKA, NKNA, TAC2, Protachykinin-1, Substance K, Neuromedin L
Reference Data
Protein Families	Druggable Genome, Secreted Protein

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