TAC1 Guinea Pig Polyclonal Antibody

Specifications

Product Data
Applications	FC, IHC
Recommend Dilution	Immunofluorescence: 1/400-1/800 with overnight incubation at 2-8°C. Immunohistochemistry on Frozen Sections. Positive Control: Frozen sections of rat colon.
Reactivity	Fish, Human, Rabbit, Rat
Host	Guinea Pig
Clonality	Polyclonal
Immunogen	Substance P conjugated to BSA
Specificity	This antibody reacts to Substance P. Absorption with 10-100 µg SP and NKA per ml diluted antiserum abolishes the staining while GRP and NKB do not.
Formulation	State: Serum State: Lyophilized serum
Reconstitution Method	Dissolve the antiserum in 50-100 µl distilled water, and dilute further in 0.1 M PBS with 1% BSA and 0.09% NaN3.
Conjugation	Unconjugated
Storage Condition	Prior to reconstitution store the antibody (undiluted) at 2-8°C. Following reconstitution store (in aliquots) at -20°C. Avoid repeated freezing and thawing.
Gene Name	tachykinin precursor 1
Database Link	Entrez Gene 24806 RatEntrez Gene 6863 Human UniProt ID P20366
Background	Substance P occurs in nerve fibers of the central and peripheral nervous system and in endocrine cells of the gut. It stimulates smooth muscle contraction, gives rise to vasodilation and is involved in sensory functions. Substance P-containing tumors arising in the ileum are often associated with the carcinoid syndrome, characterized by flushing of the skin, diarrhea, bronchoconstriction and sudden drops in blood pressure. Substance P is commonly found in the midgut carcinoids and some of the symptoms may be related to this peptide.
Synonyms	Substance-P
Reference Data
Protein Families	Druggable Genome, Secreted Protein

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