Gastrin (GAST) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC
Recommend Dilution	Immunohistochemistry on formalin-fixed paraffin embedded sections: diluted of 1:50-1:100 in an ABC method (30 minutes at room temperature) Recommended Positive Control: Stomach
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Recombinant Gastrin conjugated to KLH.
Specificity	The antibody is specific against gastrin-containing cells. This antibody reacts with human gastrin I and human gastrin I fragments. Cellular Localization: Cytoplasmic
Formulation	containing sodium azide as preservative State: Purified State: Liquid serum
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	gastrin
Database Link	Entrez Gene 2520 Human UniProt ID P01350
Background	Gastrin is mainly known by its first described role as a gastric acid-hormone but the protein also has the ability to promote cellular growth. More recently, gastrin has been suggested to induce leukocyte-endothelial cell interactions and to have a pro-inflammatory effect. Gastrin has two biologically active peptide forms, G34 and G17 and they activate two different receptors: the CCK-1 receptor, which has low affinity for gastrin but high affinity for the related hormone cholecystokinin (CCK), and the CCK-2 receptor, which has high affinity for both gastrin and CCK and mediates the acid-secretory as well as the proliferative effects of gastrin.
Synonyms	GAST, GAS
Reference Data

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