Fibronectin (FN1) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC
Recommend Dilution	Immunohistochemistry on frozen and paraffin sections: This antibody may be diluted to a titer of 1:50-1:250 in an ABC method. We suggest an incubation period of 30-60 minutes at room temperature. Formalin fixed, paraffin embedded sections require high temperature unmasking with1 mM EDTA, ph 8.0 or protease pretreatment.
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Fibronectin isolated from a pool of normal human plasma
Specificity	This antibody reacts with human fibronectin in liver, tonsil, skin and kidney. Traces of contaminating antibodies have been removed by solid-phase absorption. Only the fibronectin arch was observed in crossed immunoelectrophoresis.
Formulation	Contains 0.05 % sodium azide as preservative State: Purified State: Liquid
Purification	Purified immunoglobulin fraction
Conjugation	Unconjugated
Storage Condition	Store the antibody at 2-8 °C.
Gene Name	fibronectin 1
Database Link	Entrez Gene 2335 Human UniProt ID P02751
Background	Fibronectin is a glycoprotein present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. Fibronectin is involved in cell adhesion and migration processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis. They occur as dimers of two 250 kDa subunits. They have binding domains for bacterial proteins, collagens, heparin-like molecules and fibrin. Cellular fibronectin is widely distributed in the stroma of malignant tumours.
Synonyms	FN1, Cold-insoluble globulin, CIG
Reference Data

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