MLH1 Mouse Monoclonal Antibody [Clone ID: G168-15]

CAT#: DM430

MLH1 mouse monoclonal antibody, clone G168-15, Supernatant



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CNY 10,669.00


货期*
4周

规格
    • 1 ml

Product images

Specifications

Product Data
Clone Name G168-15
Applications IHC
Recommend Dilution Immunohistochemistry on formalin-fixed paraffin embedded sections: Dilute 1/25-1/50 in an ABC method (30 to 60 minutes at room temperature).
Formalin fixed paraffin embedded tissue sections require high temperature antigen unmasking with 10 mM citrate buffer, pH 6.0 prior to immunostaining.
Recommended Positive Control: Tonsil, colon carcinoma.
Reactivity Hamster, Human, Mouse, Rat
Host Mouse
Clonality Monoclonal
Immunogen Full length recombinant MLH.
Specificity The G168-15 antibody recognizes MLH1 80-85kDa.
Cellular Localization: Nuclear
Formulation State: Supernatant
State: Liquid Supernatant containing Sodium Azide as preservative.
Conjugation Unconjugated
Storage Condition Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Gene Name mutL homolog 1
Background The repair of mismatch DNA is essential to maintaining the integrity of genetic information over time. An alteration of microsatellite repeats is the result of slippage owing to strand misalignment during DNA replication and is referred to as microsatellite instability (MSI). These defects in DNA repair pathways have been related to human carcinogenesis. The importance of mismatch repair genes became apparent with the identification of the genetic basis for hereditary nonpolyposis colon cancer (HNPC). MSH-2 is involved in the initial cognition of mismatch nucleotides during the replication mismatch repair process. It is thought that after MSH2 binds to a mismatched DNA duplex it is joined by a heterodimer of MLH1 and PMSH, which together help facilitate the later steps in mismatch repair.
Synonyms DNA mismatch repair protein Mlh1, COCA2
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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