VEGFC Mouse Monoclonal Antibody [Clone ID: 107F10]

Specifications

Product Data
Clone Name	107F10
Applications	ELISA, WB
Recommend Dilution	ELISA: 2-10 µg/ml. Western Blot: 1-5 µg/ml.
Reactivity	Human, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant Human VEGF-C protein (Cat.-No AR01001PU-N)
Specificity	This antibody detects VEGF-C in Western Blots. No cross-reactivity is shown with VEGF-A.
Formulation	PBS without preservatives or stabilizers State: Purified State: Lyophilized (0.2 µm filtered) purified IgG fraction
Reconstitution Method	Restore in sterile water to a concentration of 0.1-1.0 mg/ml. Centrifuge vial prior to opening.
Purification	Protein G Affinity Chromatography
Conjugation	Unconjugated
Storage Condition	Store lyophilized at 2-8°C for 6 months or at -20°C long term.
Gene Name	vascular endothelial growth factor C
Database Link	Entrez Gene 7424 Human UniProt ID P49767
Background	VEGF-C, also known as Vascular Endothelial Growth Factor Related Protein (VRP), is a VEGF growth factor family member that is most closely related to VEGF-D. The human VEGF-C cDNA encodes a pre-pro-protein of 416 amino acids residues. It is almost identical to the mouse VEGF-C protein. Similar to VEGF-D, VEGF-C has a VEGF homology domain spanning the middle third of the precursor molecule and long N- and C-terminal extensions. In adults, VEGF-C is highly expressed in heart, placenta, ovary and small intestine. Recombinant human VEGF-C, lacking the N- and C-terminal extensions and containing only the middle VEGF homology domain, forms primarily non-covalently linked dimers. This protein is a ligand for both VEGFR-2/KDR and VEGFR-3/FLT-4. Since VEGFR-3 is strongly expressed in lymphatic endothelial cells, it has been postulated that VEGF-C is involved in the regulation of the growth and/or differentiation of lymphatic endothelium. Although recombinant human VEGF-C is also a mitogen for vascular endothelial cells, it is much less potent than VEGF-A.
Synonyms	VEGFC, VRP, Vascular endothelial growth factor C, Vascular endothelial growth factor-related protein, Flt4 ligand
Reference Data

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