CCL3 Mouse Monoclonal Antibody [Clone ID: 116]

Specifications

Product Data
Clone Name	116
Applications	ELISA
Recommend Dilution	ELISA. Successful use in Western blot was reported by some researchers. As this detection method has not been verified by Acris Antibodies, the application was deleted from the database. This does not necessarily exclude the use in such procedure.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Purified recombinant human MIP-1α
Specificity	This antibody reacts with recombinant MIP-1α. Does not show any cross reaction with other human cytokines or growth factors tested such as M-CSF, GM-CSF, IL-7, IL-8, IL-16, IL-1β, bFGF, TGF-β, EGF, TNF-α and EPO.
Formulation	0.01M PBS, pH 7.2 State: Purified State: Lyophilized purified IgG
Reconstitution Method	Restore with double distillated water to adjust the final concentration to 1.0 mg/ml.
Purification	Protein G affinity chromatography
Conjugation	Unconjugated
Storage Condition	Store the antibody at -20°C. Avoid repeated freezing and thawing.
Gene Name	C-C motif chemokine ligand 3
Database Link	Entrez Gene 6348 Human UniProt ID P10147
Background	Macrophage Inflammatory Protein 1 alpha (MIP1 alpha) and MIP1 beta, two closely related but distinct proteins, were originally co-purified from medium conditioned by a LPS-stimulated murine macrophage cell line. Mature mouse MIP1 alpha shares approximately 77% and 70% amino acid identity with human MIP1 alpha and mouse MIP1 beta, respectively. MIP1 proteins are expressed primarily in T cells, B cells, and monocytes after antigen or mitogen stimulation. Has adhesive effects on lymphocytes. MIP1 alpha can inhibit the proliferation of hematopoietic stem cells in vitro as well as in vivo. A signal transducing receptor, designated the C-C chemokine receptor-1 (C-C CKR-1) with seven transmembrane domains that bind MIP1 alpha, MIP1 beta, MCP1 and RANTES with varying affinities, has been isolated.
Synonyms	CCL-3, MIP-1-alpha, C-C motif chemokine 3, MIP1A, Small-inducible cytokine A3, SCYA3, LD78 alpha, G0S19-1 protein
Reference Data

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