IL13 receptor alpha 1 (IL13RA1) Mouse Monoclonal Antibody [Clone ID: GM1C8]

Specifications

Product Data
Clone Name	GM1C8
Applications	ELISA, FC, IF
Recommend Dilution	Flow cytometry: 1.2 µg/106 cells. The antibody is routinely tested by on BOSC cells transiently transfected with an IL-13Rα1 expression vector. Cell based ELISA with intakt, transiently transfected cells: 1/200-1/400. It is expected that the antibody will be suited for all applications where recognition of the native protein is required.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	cDNA of the human IL-13Rα1 chain extracellular domain (U62858).
Specificity	Clone GM1C8 recognises IL-13Rα1 transiently expressed on the cell surface of transfected BOSC cells as well as the native protein on monocytes (W. Luttmann, unpublished data). Selection: Based on recognition of the complete native protein expressed on transfected mammalian cells.
Formulation	PBS, pH 7.2 State: Purified State: Liquid purified IgG fraction Preservative: 0.01% Sodium Azide
Concentration	lot specific
Purification	Protein G chromatography
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	interleukin 13 receptor subunit alpha 1
Database Link	Entrez Gene 3597 Human UniProt ID P78552
Background	Interleukin 13 (IL-13) is a T cell derived cytokine involved in the regulation of inflammatory and im-mune responses. IL-13Rα1 together with IL-4Rα forms a functional receptor for both IL-4 and IL-13, which is why these two cytokines share many of their biological activities. The receptor is found on human B cells, monocytes and endothelial cells. However, no functional receptor is expressed on T cells, which explains why IL-13, in contrast to IL-4, fails to induce TH2-cell differentiation.
Synonyms	Interleukin-13 receptor alpha-1 chain, IL-13R-alpha-1, IL-13RA-1, IL13R, IL13RA, IL13 receptor alpha, CT19
Reference Data

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