PSMA (FOLH1) Mouse Monoclonal Antibody [Clone ID: Y-PSMA1]

Specifications

Product Data
Clone Name	Y-PSMA1
Applications	ELISA, IF, IHC, WB
Recommend Dilution	ELISA. Western blot: 1.0 µl/ml, Indentified the 100 kDa PSMA in LNcap cell extract. Immunofluorescence. Immunohistochemistry on Formalin-Fixed Paraffin Embedded and Frozen Tissue Sections.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Crude membrane protein preparation from pooled prostate malignant carcinoma.
Specificity	This antibody detects PSMA expressed LNCap cell lines. Little or no cross-reactivity to benign prostate hyperplasia (BPH) or to normal prostatic tissue.
Formulation	0.01M PBS, pH 7.0 State: Purified State: Lyophilized purified IgG fraction Stabilizer: None Preservative: None
Reconstitution Method	Restore with double distillated water to adjust the final concentration to 1.0 mg/ml.
Purification	Affinity Chromatography on Protein G
Conjugation	Unconjugated
Storage Condition	Upon receipt, store undiluted (in aliquots) at -20°C. Avoid repeated freezing and thawing.
Gene Name	folate hydrolase (prostate-specific membrane antigen) 1
Database Link	Entrez Gene 2346 Human UniProt ID Q04609
Background	PSMA (FOLH1) is a type II transmembrane glycoprotein belonging to the M28 peptidase family. Three functionally distinct proteins are encoded, including folylpoly-gamma-glutamate carboxypeptidase in the intestine, N-acetylated alpha-linked acidic dipeptidase 1 in the brain, and prostate-specific membrane antigen in the prostate. A mutation in the intestinal form may be associated with impaired intestinal absorption of dietary folates, resulting in low blood folate levels and consequent hyperhomocysteinemia. The form expressed in the brain may be involved in a number of pathological conditions associated with glutamate excitotoxicity. The prostate form is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate cancer. This gene likely arose from a duplication event of a nearby chromosomal region. Alternative splicing gives rise to multiple transcript variants.
Synonyms	Glutamate carboxypeptidase 2, Folate hydrolase 1, Prostate-specific membrane antigen, FOLH, NAALAD1, PSM, GCP2, NAALAdase
Note	Predicted Molecular weight: 84 kDa.
Reference Data

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