Cd207 Mouse Monoclonal Antibody [Clone ID: 817G7]

Specifications

Product Data
Clone Name	817G7
Applications	FC, FN
Recommend Dilution	Surface Flow cytometry, HIV-gp120 binding studies (blocks HIV-gp120). Usage recommendation: *This monoclonal antibody may be used between 5-20 μg/ml. *Optimal dilution should be determined by each laboratory for each application. *Coupled antibody: to maintain RT before use.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Human Langerin-transfected eukaryotic cells.
Specificity	Human Langerin (extracellular epitope). Species cross-reactivity: nd.
Formulation	Purified: 100 μg in 200μl / 50 μg in 100 μl Tris-NaCl pH 8. Coupled: 100 μg in 200μl / 50 μg in 100 μl PBS 50% glycerol. State: Purified
Concentration	lot specific
Purification	QMA Hyper D ion exchange chromatography
Conjugation	Unconjugated
Storage Condition	-20°C. KEEP CONTENTS STERILE: no preservative. Purified antibodies: avoid repeated freeze/thaw cycles. Coupled antibodies: glycerol protects from freezing.
Gene Name	CD207 antigen
Database Link	UniProt ID Q8VBX4
Background	Langerin/CD207 is a transmembrane C-type lectin receptor (CLR) of epidermal and mucosal Langerhans cells (LCs) that induces Birbeck granule formation. Langerin features a single carbohydrate recognition domain (CRD) with mannose-type specificity in its extracellular portion. Langerin is unique among the CLRs in that it contains an intracellular domain with a proline-rich motif. Langerin expression has not been reported outside the DC system. (Valladeau J et al, 2002 J Immunol, 168 : 782-792) (Douillard P et al, 2005 J Invest Dermatol, 125: 983–994).
Synonyms	CLEC4K, Dendritic Cell Marker
Reference Data

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