LAMP3 Rat Monoclonal Antibody [Clone ID: 1010E1.01]

CAT#: DDX0191P-100

LAMP3 rat monoclonal antibody, clone 1010E1.01



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CNY 4,988.00


货期*
4周

规格
    • 100 ug

Product images

Specifications

Product Data
Clone Name 1010E1.01
Applications IHC
Recommend Dilution IHC paraffin (formol, Bouin) in human
Reactivity Canine, Feline, Human, Mouse, Sheep
Host Rat
Clonality Monoclonal
Immunogen recombinant murine DC LAMP
Specificity murine DC-LAMP (epitope in intracytoplasmic domain).
Species cross-reactivity: human, cat, dog, sheep, mouse.
Formulation Tris-NaCl pH 8
State: Purified
Concentration lot specific
Purification QMA Hyper D ion exchange chromatography
Conjugation Unconjugated
Storage Condition -20°C. KEEP CONTENTS STERILE: no preservative.
Purified antibodies: avoid repeated freeze/thaw cycles.
Gene Name lysosomal associated membrane protein 3
Background The dendritic cell lysosomal-associated membrane protein (DC-LAMP)/CD208 is a type I integral transmembrane glycoprotein mostly homologous to CD68, of about 45 kDa in mouse and 90 kDa in human (due to extensive glycosylation), with a bipartite C-terminal structure divided by a serine/proline rich region, a transmembrane domain and a conserved tyrosine-based lysosomal targeting motif in its cytoplasmic tail. Initially cloned as a specific marker of human mature dendritic cells (DCs), DC-LAMP has been subsequently shown to be expressed in alveolar type II pneumocytes. In both cell types, DC-LAMP is found in the limiting membrane of intracellular multi-lamellar bodies, known as MIIC (MHC class II compartments) in human mature DC and as lung surfactant-containing lamellar bodies in type II pneumocytes. In the latter cell type, DC-LAMP expression is also detected at the cell surface.
(de Saint-Vis B et al, 1998 ; Immunity ; 9: 325-336 ; Salaun B et al, 2003 ; Eur. J. Immunol., 33 :9, 2619- 29 ; Salaun B et al, 2004 ; Am. J. Pathol., 164 :3, 861-71)
Synonyms DCLAMP, DC-LAMP, TSC403, Dendritic Cell Marker
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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