CD1 (CD1A) Mouse Monoclonal Antibody [Clone ID: 201B5.08]

Specifications

Product Data
Clone Name	201B5.08
Applications	FC
Recommend Dilution	DDX0081A488-50 / DDX0081A488-100 Alexa-fluor®488: Surface flow cytometry, IF. DDX0081A546-50 / DDX0081A546-100 Alexa- fluor®546 (on request): surface Flow Cytometry. DDX0081A647-50 /DDX0081A647-100 Alexa- fluor®647: Surface flow cytometry.
Reactivity	Human, Porcine
Host	Mouse
Clonality	Monoclonal
Immunogen	in vitro derived human DCs (GMCSF + TNFα)
Specificity	Human CD1a (epitope in extracellular domain). Species cross- reactivity: Pig.
Formulation	Label: Alexa Fluor 546
Concentration	lot specific
Purification	QMA hyper D ion exchange chromatography
Conjugation	Alexa Fluor 546
Storage Condition	-20°C. KEEP CONTENTS STERILE: no preservative. Purified antibodies: avoid repeated freeze/thaw cycles. Coupled antibodies: glycerol protects from freezing
Gene Name	CD1a molecule
Database Link	Entrez Gene 909 Human UniProt ID P06126
Background	CD1 family molecules have structural homologies with MHC class I molecules. They are monomorphic proteins of 50 kDa, non-covalently associated with Beta-2-microglobulin. Human CD1a molecules are divided in 2 groups. Group 1 includes CD1a, CD1b, and CD1c, while group 2 consists of the CD1d molecule. CD1a is mainly expressed at the cell-surface and in recycling vesicles. CD1a occurs in Birbeck granules of Langerhans cells and plays a role in presentation of non-peptide antigens. CD1a is expressed in vitro on CD34+-generated DCs and on monocyte-derived DCs. (Burdin N. et al., 1999, Curr Opin Immunol, 11:326-31).
Synonyms	T6/Leu-6, hTa1
Reference Data

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