Xanthine Oxidase (XDH) Mouse Monoclonal Antibody [Clone ID: OTI1C10]

Specifications

Product Data
Clone Name	OTI1C10
Applications	WB
Recommend Dilution	WB 1:500
Reactivity	Human, Mouse, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Human recombinant protein fragment corresponding to amino acids 1-280 of human XDH (NP_000370) produced in E.coli.
Formulation	Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)
Reconstitution Method	For reconstitution, we recommend adding 100uL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiment, we strongly recommend performing another round of desalting process. (OriGene recommends Zeba Spin Desalting Columns, 7KMWCO from Thermo Scientific)
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	146.2 kDa
Gene Name	xanthine dehydrogenase
Database Link	NP_000370 Entrez Gene 22436 MouseEntrez Gene 497811 RatEntrez Gene 7498 Human UniProt ID P47989
Background	Xanthine dehydrogenase belongs to the group of molybdenum-containing hydroxylases involved in the oxidative metabolism of purines. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Xanthine dehydrogenase can be converted to xanthine oxidase by reversible sulfhydryl oxidation or by irreversible proteolytic modification. Defects in xanthine dehydrogenase cause xanthinuria, may contribute to adult respiratory stress syndrome, and may potentiate influenza infection through an oxygen metabolite-dependent mechanism. [provided by RefSeq, Jan 2014]
Synonyms	XAN1; XO; XOR
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Caffeine metabolism, Drug metabolism - other enzymes, Metabolic pathways, Purine metabolism

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