M6PR Mouse Monoclonal Antibody [Clone ID: OTI2F3]

Specifications

Product Data
Clone Name	OTI2F3
Applications	WB
Recommend Dilution	WB 1:500
Reactivity	Human, Dog, Monkey, Mouse, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Human recombinant protein fragment corresponding to amino acids 27-185 of human M6PR (NP_002346) produced in E.coli.
Formulation	Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)
Reconstitution Method	For reconstitution, we recommend adding 100uL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiment, we strongly recommend performing another round of desalting process. (OriGene recommends Zeba Spin Desalting Columns, 7KMWCO from Thermo Scientific)
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	30.99 kDa
Gene Name	mannose-6-phosphate receptor, cation dependent
Database Link	NP_002346 Entrez Gene 17113 MouseEntrez Gene 312689 RatEntrez Gene 477700 DogEntrez Gene 716696 MonkeyEntrez Gene 4074 Human UniProt ID P20645
Background	Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. [UniProtKB/Swiss-Prot Function]
Synonyms	CD-M6PR; CD-MPR; MPR-46; MPR 46; MPR46; SMPR
Reference Data
Protein Families	Druggable Genome, Transmembrane
Protein Pathways	Lysosome

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