PIN1 Mouse Monoclonal Antibody [Clone ID: OTI4H1]

Specifications

Product Data
Clone Name	OTI4H1
Applications	WB
Recommend Dilution	WB 1:500
Reactivity	Human, Rat, Mouse
Host	Mouse
Clonality	Monoclonal
Immunogen	Full length human recombinant protein of human PIN1 (NP_006212) produced in E.coli.
Formulation	Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)
Reconstitution Method	For reconstitution, we recommend adding 100uL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiment, we strongly recommend performing another round of desalting process. (OriGene recommends Zeba Spin Desalting Columns, 7KMWCO from Thermo Scientific)
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	18.1 kDa
Gene Name	peptidylprolyl cis/trans isomerase, NIMA-interacting 1
Database Link	NP_006212 Entrez Gene 23988 MouseEntrez Gene 298696 RatEntrez Gene 5300 Human UniProt ID Q13526
Background	Peptidyl-prolyl cis/trans isomerases (PPIases) catalyze the cis/trans isomerization of peptidyl-prolyl peptide bonds. This gene encodes one of the PPIases, which specifically binds to phosphorylated ser/thr-pro motifs to catalytically regulate the post-phosphorylation conformation of its substrates. The conformational regulation catalyzed by this PPIase has a profound impact on key proteins involved in the regulation of cell growth, genotoxic and other stress responses, the immune response, induction and maintenance of pluripotency, germ cell development, neuronal differentiation, and survival. This enzyme also plays a key role in the pathogenesis of Alzheimer's disease and many cancers. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2011]
Synonyms	DOD; UBL5
Reference Data
Protein Families	Druggable Genome
Protein Pathways	RIG-I-like receptor signaling pathway

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