PTPN22 Mouse Monoclonal Antibody [Clone ID: OTI6B1]

Specifications

Product Data
Clone Name	OTI6B1
Applications	IHC, WB
Recommend Dilution	WB 1:2000, IHC 1:1000
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Human recombinant protein fragment corresponding to amino acids 359-449 of human PTPN22 (NP_057051) produced in E.coli.
Formulation	Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)
Reconstitution Method	For reconstitution, we recommend adding 100uL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiment, we strongly recommend performing another round of desalting process. (OriGene recommends Zeba Spin Desalting Columns, 7KMWCO from Thermo Scientific)
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	91.5 kDa
Gene Name	protein tyrosine phosphatase non-receptor type 22
Database Link	NP_057051 Entrez Gene 26191 Human UniProt ID Q9Y2R2
Background	This gene encodes of member of the non-receptor class 4 subfamily of the protein-tyrosine phosphatase family. The encoded protein is a lymphoid-specific intracellular phosphatase that associates with the molecular adapter protein CBL and may be involved in regulating CBL function in the T-cell receptor signaling pathway. Mutations in this gene may be associated with a range of autoimmune disorders including Type 1 Diabetes, rheumatoid arthritis, systemic lupus erythematosus and Graves' disease. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Mar 2009]
Synonyms	LYP; LYP1; LYP2; PEP; PTPN8
Reference Data
Protein Families	Druggable Genome, Phosphatase

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