ROR1 Mouse Monoclonal Antibody [Clone ID: OTI3F8]

Specifications

Product Data
Clone Name	OTI3F8
Applications	IHC, WB
Recommend Dilution	WB 1:500, IHC 1:2000
Reactivity	Human,Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Full length human recombinant protein of human ROR1 (NP_005003) produced in HEK293T cell.
Formulation	Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)
Reconstitution Method	For reconstitution, we recommend adding 100uL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiment, we strongly recommend performing another round of desalting process. (OriGene recommends Zeba Spin Desalting Columns, 7KMWCO from Thermo Scientific)
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation	Unconjugated
Storage Condition	Shipped at -20°C or with ice packs, Upon delivery store at -20°C. Dilute in PBS(pH7.3) if necessary. Stable for 12 months from date of receipt. Avoid repeated freeze-thaws.
Predicted Protein Size	104.1 kDa
Gene Name	receptor tyrosine kinase like orphan receptor 1
Database Link	NP_005003 Entrez Gene 362550 RatEntrez Gene 4919 Human UniProt ID Q01973
Background	This gene encodes a receptor tyrosine kinase-like orphan receptor that modulates neurite growth in the central nervous system. The encoded protein is a glycosylated type I membrane protein that belongs to the ROR subfamily of cell surface receptors. It is a pseudokinase that lacks catalytic activity and may interact with the non-canonical Wnt signalling pathway. This gene is highly expressed during early embryonic development but expressed at very low levels in adult tissues. Increased expression of this gene is associated with B-cell chronic lymphocytic leukaemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2012]
Synonyms	dJ537F10.1; NTRKR1
Reference Data
Protein Families	Druggable Genome, Protein Kinase, Transmembrane

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