TRIF (TICAM1) Mouse Monoclonal Antibody [Clone ID: OTI1G7]

Specifications

Product Data
Clone Name	OTI1G7
Applications	WB
Recommend Dilution	WB 1:2000
Reactivity	Human, Monkey
Host	Mouse
Clonality	Monoclonal
Immunogen	Human recombinant protein fragment corresponding to amino acids 120-420 of human TICAM1 (NP_891549) produced in E.coli.
Formulation	Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)
Reconstitution Method	For reconstitution, we recommend adding 100uL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiment, we strongly recommend performing another round of desalting process. (OriGene recommends Zeba Spin Desalting Columns, 7KMWCO from Thermo Scientific)
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	76.2 kDa
Gene Name	toll like receptor adaptor molecule 1
Database Link	NP_891549 Entrez Gene 574294 MonkeyEntrez Gene 148022 Human UniProt ID Q8IUC6
Background	This gene encodes an adaptor protein containing a Toll/interleukin-1 receptor (TIR) homology domain, which is an intracellular signaling domain that mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. This protein is involved in native immunity against invading pathogens. It specifically interacts with toll-like receptor 3, but not with other TLRs, and this association mediates dsRNA induction of interferon-beta through activation of nuclear factor kappa-B, during an antiviral immune response. [provided by RefSeq, Jan 2012]
Synonyms	IIAE6; MyD88-3; PRVTIRB; TICAM-1; TRIF
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Toll-like receptor signaling pathway

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